diff --git a/src/core/gpu_hw.cpp b/src/core/gpu_hw.cpp
index b9190fbbc..c0f0f6150 100644
--- a/src/core/gpu_hw.cpp
+++ b/src/core/gpu_hw.cpp
@@ -557,10 +557,8 @@ void GPU_HW::UpdateSettings(const Settings& old_settings)
   {
     GPUTextureCache::Shutdown();
   }
-  else if (m_use_texture_cache)
-  {
-    GPUTextureCache::UpdateSettings(old_settings);
-  }
+
+  GPUTextureCache::UpdateSettings(m_use_texture_cache, old_settings);
 
   if (g_settings.gpu_downsample_mode != old_settings.gpu_downsample_mode ||
       (g_settings.gpu_downsample_mode == GPUDownsampleMode::Box &&
diff --git a/src/core/gpu_hw_texture_cache.cpp b/src/core/gpu_hw_texture_cache.cpp
index b29be92a7..29d8f6a9e 100644
--- a/src/core/gpu_hw_texture_cache.cpp
+++ b/src/core/gpu_hw_texture_cache.cpp
@@ -561,28 +561,38 @@ bool GPUTextureCache::Initialize()
   return true;
 }
 
-void GPUTextureCache::UpdateSettings(const Settings& old_settings)
+void GPUTextureCache::UpdateSettings(bool use_texture_cache, const Settings& old_settings)
 {
-  UpdateVRAMTrackingState();
-
-  if (g_settings.texture_replacements.enable_texture_replacements !=
-      old_settings.texture_replacements.enable_texture_replacements)
+  if (use_texture_cache)
   {
-    Invalidate();
+    UpdateVRAMTrackingState();
 
-    DestroyPipelines();
-    if (!CompilePipelines()) [[unlikely]]
-      Panic("Failed to compile pipelines on TC settings change");
+    if (g_settings.texture_replacements.enable_texture_replacements !=
+        old_settings.texture_replacements.enable_texture_replacements)
+    {
+      Invalidate();
+
+      DestroyPipelines();
+      if (!CompilePipelines()) [[unlikely]]
+        Panic("Failed to compile pipelines on TC settings change");
+    }
   }
 
   // Reload textures if configuration changes.
   const bool old_replacement_scale_linear_filter = s_config.replacement_scale_linear_filter;
-  if (LoadLocalConfiguration(false, false))
+  if (LoadLocalConfiguration(false, false) ||
+      g_settings.texture_replacements.enable_texture_replacements !=
+        old_settings.texture_replacements.enable_texture_replacements ||
+      g_settings.texture_replacements.enable_vram_write_replacements !=
+        old_settings.texture_replacements.enable_vram_write_replacements)
   {
-    if (s_config.replacement_scale_linear_filter != old_replacement_scale_linear_filter)
+    if (use_texture_cache)
     {
-      if (!CompilePipelines()) [[unlikely]]
-        Panic("Failed to compile pipelines on TC replacement settings change");
+      if (s_config.replacement_scale_linear_filter != old_replacement_scale_linear_filter)
+      {
+        if (!CompilePipelines()) [[unlikely]]
+          Panic("Failed to compile pipelines on TC replacement settings change");
+      }
     }
 
     ReloadTextureReplacements(false);
diff --git a/src/core/gpu_hw_texture_cache.h b/src/core/gpu_hw_texture_cache.h
index f070b8859..dd629a40f 100644
--- a/src/core/gpu_hw_texture_cache.h
+++ b/src/core/gpu_hw_texture_cache.h
@@ -103,7 +103,7 @@ struct Source
 };
 
 bool Initialize();
-void UpdateSettings(const Settings& old_settings);
+void UpdateSettings(bool use_texture_cache, const Settings& old_settings);
 bool DoState(StateWrapper& sw, bool skip);
 void Shutdown();
 
diff --git a/src/core/system.cpp b/src/core/system.cpp
index 55ad064c9..1b9a89e30 100644
--- a/src/core/system.cpp
+++ b/src/core/system.cpp
@@ -4418,6 +4418,11 @@ void System::CheckForSettingsChanges(const Settings& old_settings)
         g_settings.display_line_end_offset != old_settings.display_line_end_offset ||
         g_settings.rewind_enable != old_settings.rewind_enable ||
         g_settings.runahead_frames != old_settings.runahead_frames ||
+        g_settings.texture_replacements.enable_texture_replacements !=
+          old_settings.texture_replacements.enable_texture_replacements ||
+        g_settings.texture_replacements.enable_vram_write_replacements !=
+          old_settings.texture_replacements.enable_vram_write_replacements ||
+        g_settings.texture_replacements.dump_textures != old_settings.texture_replacements.dump_textures ||
         g_settings.texture_replacements.config != old_settings.texture_replacements.config)
     {
       g_gpu->UpdateSettings(old_settings);